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The rodent Non-Invasive Blood Pressure Monitor is a device used to measure blood pressure in small animals such as Rats and Mice without causing any harm or distress to the animal.
The monitor is designed to use non-invasive techniques, meaning it does not require any surgical procedures or the insertion of a catheter into the animal’s arteries, which can be traumatic and increase the risk of infection.
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ConductScience introduces the Non-Invasive Blood Pressure Monitor system to measure systemic blood pressure and cardiovascular parameters in mice and rats without any invasive catheterization. Our models can examine single or multiple animals (1-6) at once and can measure the following parameters:
*The number of channels corresponds to the number of animals that can be monitored simultaneously.
ConductScience introduces the Non-Invasive Blood Pressure Monitor system to measure systemic blood pressure and cardiovascular parameters in mice and rats without any invasive catheterization. Our models can examine single or multiple animals (1-6) at once and can measure the following parameters:
TCH-BP-100A/300A/600A fully automatic non-invasive blood pressure measurement system is a computer-controlled non-invasive blood pressure measurement and processing system for rats and mice.
All measurement operations are computer-based. This system is used to observe the arterial blood pressure of animals in chronic experiments. The animals do not require anesthesia, are non-invasive and are easy to use. The system adopts the internationally popular tail-cuff method non-invasive blood pressure measurement principle and is suitable for rats, etc.
The software automatically calculates the mean and standard deviation of the retrieved data, which is shown on a numeric table displayed on the control unit and can be exported to Excel.
The Rodent’s Blood Pressure Device consists of a:
The specimen platform and holder come in different variations for mice and rats. The difference lies in the size of the cages in which the tail cuffs and sensory assembly are larger for rats.
The specimen platform consists of a sensory assembly and tail cuff.
The cuff gradually inflates around the animal’s tail when acquiring its blood pressure. Gradual inflation is performed to avoid alarming the animal about ceasing blood flow.
The sensor includes a magnetic top for easy removal while situating the animal. It also makes it more secure once the tail is in place, which drastically reduces tail movement. The tail cuff and sensory assembly are suitable for mice and rats of all sizes without requiring modifications.
The tail cuffs contain a built-in air pump that allows automated inflation and deflation of the cuff at a constant and even rate. Automated deflation of the cuff is performed after each subject reaches their systolic value to prevent the animal’s tail from deteriorating from high occlusion pressures. Therefore, real values are achieved and are easily traceable through charting.
The specimen holders for mice have magnetic bases for restraining and positioning the animal quickly. The holders are available in three sizes and can accommodate mice over 60 grams. It can also accommodate neonatal rats.
The specimen tray is used to protect the specimen platform’s surface and make cleaning the system easier. Moreover, the animals can be easily transferred to the specimen platform from any loading station using the specimen tray.
The power/utility unit provides power and air to the specimen platform. Each unit can accommodate a single, three and six-channel specimen platform. It includes a universal power supply, making it compatible for international use.
The control unit displays the animal’s heart rate, blood pressure, and other numerical data.
The pulse transducer measures the pressure applied to the pressure cuff.
The software controls the specimen platform, determines measurement parameters, initializes measurements, displays waveforms in real-time, and saves results.
Literature Review
Herat et al. (2020) compared the retinal neural structure of the hypertensive BPH/2J mouse and its control counterpart, the normotensive BPN/3J strain. The experimenters determined whether the retinal neural phenotype in the BPH/2J strain was because of an increase in blood pressure by investigating the neural retina of both mice strains. Mice (4, 6, 13, 17, or 21-week-old) were used in the study. The Rodent’s Blood Pressure Device was used to measure the animals’ blood pressure when they were 6 and 13 weeks. The animals were euthanized after the experiment to retrieve their eye specimen for analysis. Blood pressure results revealed that the systolic, diastolic, and mean arterial blood pressure was greater in hypertensive BPH/2J mice than in the normotensive BPN/3J mice. Analysis of the subjects’ retinas revealed severe retinal neural damage in the BPH/2J strain even at 4 weeks. Therefore, the results suggested that high blood pressure may be the cause of the retinal phenotype in the BPH/2J mouse strain.
Investigation of the effect of anakinra in reducing renal inflammation, structural damage, and blood pressure in mice with hypertension
Ling et al. (2017) investigated whether anakinra, a clinically-utilized IL-1 receptor antagonist, can reduce renal inflammation, structural damage, and blood pressure (BP) in mice with hypertension. Male C57BL/6J mice 10-12 weeks were used in the study and were induced with hypertension by uninephrectomy, deoxycorticosterone acetate (2.4 mg/d, s.c.), and replacing their drinking water with saline (1K/DOCA/salt). Anakinra (75 mg/kg/d, i.p.) treatment was commenced 10 days following surgery and was administered for 11 days. The Rodent’s Blood Pressure Device was used to measure the animals’ systolic blood pressure. Inflammatory markers, collagen, and immune cell infiltration in the kidneys were measured using immunohistochemistry and flow cytometry. The results indicated elevated systolic blood pressure in the 1K/DOCA/salt-treated mice compared to control mice. Moreover, anakinra decreased the amount of collagen in the kidneys; however, it strangely appeared to worsen the renal and glomerular hypertrophy that accompanied 1K/DOCA/salt-induced hypertension.
Investigation of the effect of ergot alkaloid mycotoxins on the physiological functions and metabolism of mice
Reddy et al. (2020) investigated the effect of ergot alkaloids, ergovaline, and ergotamine, on the physiological functions and metabolism of mice. The blood pressure, including systolic and diastolic pressure, and heart rate of ergovaline and ergotamine-treated mice were measured using the Rodent’s Blood Pressure Device to assess the effect of the mycotoxins. The relative abundances of both ergotamine and its metabolic products in body and brain tissue were determined using metabolite profiling. The animals’ motor coordination was also analyzed using an accelerating rotarod. Similar cardiovascular effects were seen between ergometrine and ergovaline in which there were elevations in blood pressure and reduced heart rate. The results also revealed that despite no changes in blood pressure, bradycardia was maintained at low ergovaline levels. Ergotamine was found in the kidney, liver, and brainstem but not in other parts of the brain, indicating that the toxin has effects that are specific to each of these organs. The rotarod test revealed no significant impairment in motor coordination 50 min post-treatment.
The Rodent’s Blood Pressure Device allows the non-invasive measurement of rodents’ blood pressure and heart rate. It provides accurate heart rate and blood pressure monitoring without any pain, injuries, embolism, or infection that are common with the long-term use of invasive systems, such as the A-line catheter. The device can be used on a single animal or up to eight animals. The device comes in separate versions for mice and rats with holders of various sizes, ensuring that each animal is properly secured to the device according to its size and weight. The holders are specifically designed to reduce stress in the animals. The tail cuff automatically inflates and deflates, making it easier for the experimenter to retrieve the animal’s blood pressure while avoiding injury after the systolic pressure is reached. The software included with the device determines measurement parameters and performs several other tasks. The device can obtain fifteen measurements per mouse or rat in less than fifteen minutes
| Species | Mouse, Rat |
|---|---|
| Channels | Single Channel, Three Channels, Six Channels |
| Brand | Techman |
| Volts | 110V, 220V |
| Product Application | Surgical Instruments, Vital Signs Monitoring Devices |
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DISCLAIMER: ConductScience and affiliate products are NOT designed for human consumption, testing, or clinical utilization. They are designed for pre-clinical utilization only. Customers purchasing apparatus for the purposes of scientific research or veterinary care affirm adherence to applicable regulatory bodies for the country in which their research or care is conducted.
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